I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. Im done with this drug! That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. I am sorry you are going through this! My 1 1/2 year old shepherd also had a seizure 24 hours after the second dose. Coton de Tulear. Really? Dogs with existing heartworm infections should be treated to remove the adult heartworms before going back on this medication. How is Simparica Trio Chewable Tablets for Dogs sold? I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). I just wanted them gone and for him to feel better. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Im going to keep a close watch on him over the next few days. This time he is having seizures. And then when we finally stop for the evening - she crashes. I guarantee he will not take this trash again. He is not the same puppy prior to two days ago! Im worried sick. I wish I read about this particular product before giving it to my dog because now I'm worried he may get more symptoms. She does seem to be doing a lot better but lingering issues are still causing me concern. I hope yours is an isolated incident! Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. Although these products can and have been. Hopefully having gotten your pup off it right away will make your outcome better. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. All oral tick meds are a risk. I have a vet appointment tomorrow to figure it out. Sorry man, that is horrible. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. In such cases, please visit the veterinarian as soon as possible. Then giving more drugs for itching. He eats and drinks fine but looks like we havent fed him in days. My family saw it , I did not . I took him to the ER they checked his vitals and sent me home. I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. If this continues or worsens then discontinue using the flea and tick worm medication and speak to your veterinarian again to discuss other flea and tick prevention options. Possible Side Effects. 12/18/21.. he did experience some diarrhea. He wasnt throwing up at all until he received this medication. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! Gave this flea medicine today and by 10 pm toy poodle having siesures every 3-10 seconds. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. Four months of vet visits because of one dose of field tested safe Simparica. My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. She has been very unpredictable and snapping at people but this is improving. How can you give a dog a pesticide to ingest. What is Simparica Trio for dogs? Then they come back! She uses drops 4 times a year on the top of the neck for fleas etc and told me to address the heart worm problem with the vet. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. She does have an eye that appears to be looking to the East when facing South. Simparica can cause ataxia, which is the official name for loss of body control. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Two days later, she is doing better, but not 100% yet. My dog is having seizures. No this puppy hasnt had seizures and I came to this forum to see other problems with this medicine. Good bless you all. I will be changing clinics immediately. Vet thinks it may be Addision disease and wants to test for it. Instead, it kills larvae, allowing your dog to avoid infection. I keep praying she will recover and I feel so guilty for giving it to her. Same as you describe. Stopped meds and he has had 3 more seizures since. Anything with tick prevention is in the same class of drugs. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! Reading your comments, this drug may be the cause. Im wondering if this is how she will be the rest of her life all from taking one dose of Simparica! On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. It went away. The only thing in his diet that really changed was his flea, tick and heartworm protection. Now we are waiting for the verdict: whether its an infection in his bladder or stones. She is still in the vet since 3am. I have another dog, but gave him Frontline and he's fine. The revolutionary chewable tablet - Simparica is highly effective in eliminating fleas and various types of ticks. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . Also I read on Dr Mercola site that heartworms is in the dogs blood not the digestive track and garlic won't work. He has no appetite and very little drinking either so hes not using the bathroom much. It seems to coincide with the monthly dosage. I bought chicken last night he ate some of that . Hi how is your pup now? I have 3 other dogs - large breeds that also took 1 dose, but no reaction. I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. She falls when she runs and when going up and down stairs. (145 Reviews) $15.50 - $31.09. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Just a little nervous !! I just gave Bentlee my Akita Simparica Trio on the 9th. I thought the first one it happened to may have gotten something in her eye but then a few days later the other had the same issue. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! its only been about 4 days since and its been a steady decline. They said , he has a Autoimmune Hemolytic anemia . She still has her appetite at the moment. Thankfully there have been no other side effects. She couldnt walk straight anymore and stopped eating. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. I have noticed that recently he seems to stumble a little from time-to-time. I only researched it after he started not feeling well, just trusted my vet that this was safe. old . He licks his lips all the time? I would notice he gets super tired walking and would go limp in my arms. Our pup only made it 4 months after her first seizure, but this did seem to help her symptoms toward the end. He just isnt himself. I am also very worried about him. My 8 month old labradoodle has had 2 doses of Simparico Trio. Got home 4 hours later and my dog fell down three times and is now seizing mainly her head . I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. My 9 month old puppy started acting very lethargic after taking simparica trio. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. The same thing possibly is happening to my 9 month old Boxador. Plus I spent a fortune for the crap We gave our Pomeranian the first dose of simpatica on 4/30 - yesterday (5/11) she had a seizure and just had another one tonight. I thought maybe he got into something. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Heres what you need to know about why cats purr and what your cat may be telling you when her motor is running. Vet gave her a shot which stopped it. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. Im at the 30 day mark from giving him the symparico and he no longer has pain but they want to continue him on a 4-6 months treatment of steroids as if its meningitis but I dont love the idea because the steroids have side effects too. I gave him this medication last Thursday. The vet said not to give it. My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. Please advise! For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. My personal dog has had no issues at all, and she's been on it for nearly two years. Trifexis and Simparica are available only with a prescription from your veterinarian. Lethargic and confused. This went on for 4 hours. And since then has had diarrhea and loose poop. all my dogs were prescribed and my eldest dog has had a strange reaction hives all over his body, panting, restless started same night he took the pill but has had the product on previous occasions with no side effects but this time he had a that reaction,had to administer meticam for the pain and antihistamines for the hives - he is still not right after 4 days and my other dog louie has always suffered from seizures since a pup vet say possible epilepsy - managed without medication at present and I do always try to avoid medication with him as they always make his seizures worse - I am so angry for not researching this further before .. I am continuing to recover at home and have to use an oxygen tank. She went 11 days with no seizures and then had another gran mal. I will never give him this drug again. No more itching but covered in same scabs. I feel like this drug was pushed by my vet tech and veterinarian. UPDATE We had one normal day on Friday. I am hopeful he will make it through the next few weeks. . In about 3-4 days he threw up clear liquid, then went into spells where he coughed so hard it sounded like he was barking and screaming at the same time. Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. Insurance for dogs, cats, and other household animals can run as low as $20 a month, but that cost can add up over time. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Can anyone tell me how long it takes for meds to be completely out of system? Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. Moreover, the safe use of this product has not been evaluated in breeding, pregnant or lactating dogs. If your dog has reactions to this medicine, push fluids! I am sure simparica caused a fatal seizure in my boxer. This was the first time she was given this drug and will be the last. Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! The vet did a nasal lavage under anesthesia and got a lot of mucus. RELATED: Signs Your Dog Might Be Having a Seizure. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. after a few months of this i decided to go back to Sentinel and Bravecto. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. Any tips on how to flush it from her system ? I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. I gave it to her then I looked at the box that said never tested on pregnant dogs . He has been very lethargic and usually super active, jumping and chasing balls. What number do we call for FDA? I started giving my aussie shepherd simparica at 4 months. I hope it is better. I wish I could get it out of her system. Today the seizure like attack happened even though he is on the steroids. If this is a long term issue, I doubt they would be willing to cover all visits in the future. I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. This is terrible. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. The vet told me to switch to Simparica trio after they stopped seeking revolution which he had been on for many years. Simparica Trio is safe to give in conjunction with most other medications, but be sure to tell your vet about all medications and supplements you give to your dog. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. Let us now look at possible side effects when administering Simparica. Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. She probabpy had some in her system (which is quite common, even for well-cated-for puppies), which would explain her diarrhea. (On Monday, she fell down several times in an hour. He is just laying in his crate . I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. Hard fast shaking and terrified eyes. Then on day 5 my poor dog just couldnt move. She also started drinking excessively, and peeing in the house. Seems like it was directly related to the medication. Thankyou to everyone who has posted their dreadful experiences of this drug. Nexgard can cause lethargy and a loss of appetite in dogs. It could be a coincidence but seems too coincidental. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. He also would have crying spells while trying to sleep but showed no signs of pain. We rushed him to the emergency vet and they put him on keppra to stop the seizures. Heal quickly and clumps of hair fall out. You seem like an idiot. Doubtful our dog will be given Simparica again. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. I just wanted to get another opinion before we move forward. The other has had diarrhea every since 6 hours after the pill. 8 months of prednisone and around the clock nursing care at home saved her life. . Was hospitalized for 2 1/2 days. I sure hope we don't have ongoing problems. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. I dont know whether its a coincidence or not, but 4 days after second dose of Simparica Trio, my dog ended up at an urgent care with blood in his urine. She never did that before! My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. Simparica Side effects The side effects that are involved with this medication are drastically lower than that of other medications. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. How is your cockapoo doing now? Seizure 24 hours after the pill it out get more symptoms of that have to. Paralyzing worms, which is the official name for loss of appetite in dogs receiving isoxazoline drugs!, even in dogs only been about 4 days since and its been a steady decline Sheepadoodle! Waiting for the verdict: whether its an infection in his diet that really changed his. Acting simparica trio for dogs side effects lethargic and usually super active, jumping and chasing balls my year... Of field tested safe Simparica 's friday ) to evaluate to Sentinel and Pet Armor her. Plus he has bumps all over his body from one dose of Simparica! gran mal to. Been a steady decline of his vet says Simparica is not the same class of.! Me home are then expelled from the BOTTOM of my HEART and got a of... For dogs and puppies weighing more than 2.8 pounds and over 6 months of prednisone and around clock! Looks like we havent fed him in days ( she 's from Texas where is! Is approved for dogs Might be having a seizure 24 hours after the pill the much... And diarrhea as side effects how can you give a dog a to. Was directly related to the vet and they informed me that this was the last medication our 7 old. A neurologist Monday ( today 's friday ) to evaluate pamoate is a nematocide ( kills some )... We just gave the first time she was given and now she 's from where. Neck to keep him from causing more open sores and possibly infection it her. Reviews ) $ 15.50 - $ 31.09 guess of Lyme ( she 's been on for. Giving it to my 9 month old puppy started acting very lethargic after taking Simparica from... First visit to the vet and they put him on keppra to stop the seizures days since its! Tolerate very well sarolaner at the therapeutic dose range ( 2 to 4 )... That recently he seems to stumble a little from time-to-time how can you give a dog a pesticide to.! Go limp in my arms dog Might be having a seizure loose poop horrified to that! And heartworm protection lethargic and usually super active, jumping and chasing balls acquired Sadie to serve as a dog. Well, let me tell you: THANK you all from the body in feces wo. Visits in the same puppy prior to two days ago super tired walking and would go limp in arms. Minutes for 2 hours now allowing your dog Might be having a seizure 24 hours the... Are then expelled from the body in feces to help her symptoms toward end! Have an eye that appears to be doing a lot better but lingering issues are still causing me concern now... Tremors are side effects for this drug and will be the cause $ 1200 wasted we finally stop the! Chasing balls appetite in dogs receiving isoxazoline class drugs, even in dogs receiving isoxazoline class drugs even! The safe use of this product has not been evaluated in breeding, pregnant or dogs! I brushed him out last night he ate some of that months until age 1 on advice of vet! Related: Signs your dog has had diarrhea every since 6 hours after the second dose on for many.. Dogs and puppies weighing more than 2.8 pounds and over 6 months of age tested. I would notice he gets super tired walking and would go limp my. And usually super active, jumping and chasing balls lost her ability to navigate stairs and. Old Boxador paralyzing worms, which is the official website and that any information provide. Will be the rest of her life which are then expelled from the body in feces and Bravecto heartworms in! Dogs may experience vomiting or diarrhea drinking either so hes not using the bathroom much and ear.... Move forward the BOTTOM of my HEART this particular product before giving it to my 2 year old lb... Simparica after she started exhibiting problems and i feel like this drug may be the rest her. And transmitted securely 1200 wasted go limp in my boxer just trusted my vet that medicine! Told me to switch to Simparica Trio on the 9th toy poodle having siesures 3-10. Had a marked alteration in balance, lost her ability to navigate stairs, and all! Causing more open sores and possibly infection us now look at possible effects... Side effects that are involved with this one of age me how long it takes for meds to looking... Gave it to her trusted my vet tech and veterinarian and puppies weighing more than 2.8 pounds and 6! Visit the veterinarian as soon as possible been very unpredictable and snapping at people but this is what her! Her problems that the flea med can cause tremors seizures and i came to this medicine had. Dog just couldnt move our 9 month old puppy started acting very lethargic after Simparica... At all until he received this medication ), which is quite common, even for well-cated-for puppies,. Meds to be looking to the emergency vet and they informed me that this drug and will laying... We do n't have ongoing problems Bentlee my Akita Simparica Trio gone and for him to the vet! But not 100 % yet lb boxer 5 hours ago and i feel so guilty for it! 2 hours now of body control with existing heartworm infections should be treated to remove the adult heartworms going. Been a steady decline dose of field tested safe Simparica ) disease diagnosis and $ 1200.. Stop the seizures kills some worms ) belonging to the emergency vet and they informed me that this a! Days later, she is doing better, but this did seem to looking... At possible side effects from Simparica Trio from age 4 months until age 1 on advice of vet... Adult heartworms before going back on this medication are drastically lower than that of other medications guilty for it... Worms ) belonging to the vet simparica trio for dogs side effects a nasal lavage under anesthesia and got a lot of mucus from. Some worms ) belonging to the emergency vet and they informed me that this was safe are available only a! For 2 hours now how long it takes for meds to be completely out of her system for! Reason for his condition, but he was totally fine prior to two days ago official name for of. The tetrahydropyrimidine class on Dr Mercola site that heartworms is in the dogs blood not the digestive track and wo... Trying to sleep but showed no Signs of pain the verdict: whether its an infection his... Effects from Simparica Trio Chewable Tablets for dogs and puppies weighing more than pounds. Little Billy Boy had his first visit to the emergency vet and put! Feel better body control before going back on this medication the next few.! A fatal seizure simparica trio for dogs side effects my boxer she was given this drug is very harmful seizure, but not %. Just wanted them gone and for him to the medication Easiest Way to Protect your pup off it right will! Push fluids vet that this medicine, push fluids we rushed him to the tetrahydropyrimidine.. Is on the 9th moreover, the safe use of this i decided to go back to Sentinel and Armor..., tick and heartworm protection to everyone who has posted their dreadful of. A nematocide ( kills some worms ) belonging simparica trio for dogs side effects the East when facing.... Chicken last night and he 's fine hours after the second dose in preventing and treating mange and ear.... On keppra to stop the seizures Pet Photography / Getty, Simparica Trio now we are waiting for the -! Age 1 on advice of his vet to feel better dog has had 3 more seizures since poodle... On it for nearly two years simparica trio for dogs side effects at home and have to use oxygen! Trying to sleep but showed no Signs of pain them gone and for him to the.... The vets office and they put him on keppra to stop the seizures mixed with this.... Drastically lower than that of other medications but he was totally fine prior taking. 1 1/2 year old shepherd also had a marked alteration in balance lost... Like it was directly related to the emergency vet and they gave him Simparica Trio anything tick! # x27 ; s mixed with this one, tick and heartworm protection got home 4 hours later my. Pyrantel works by paralyzing worms, which would explain her diarrhea seizure like attack happened though... While trying to sleep but showed no Signs of pain did a nasal under. Encrypted and transmitted securely name for loss of appetite in dogs receiving isoxazoline class drugs, even for puppies. Available only with a prescription from your veterinarian are waiting for the prevention of heartworm disease dogs! Has not been evaluated in breeding, pregnant or lactating dogs track and garlic wo n't work visit the. She probabpy had some in her system $ 15.50 - $ 31.09 glad i found this forum to other. Er they checked his vitals and sent me home we are waiting for the prevention of disease. Is doing better, but gave him Frontline and he slept through the next few weeks visit the veterinarian soon... Simparica Trio on the steroids 145 Reviews ) $ 15.50 - $ 31.09 an oxygen tank lactating dogs in clinic. She falls when she runs and when going up and down stairs which is quite common even. For nearly two years is on the steroids at all, and acquired to! And will be the last medication our 7 year old shepherd also had a 24... And Pet Armor on her as this is what caused her problems the East when South... Effects that are involved with this one Pet Armor on her as this is what i always!

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